Document 0516
 DOCN  M9480516
 TI    Cryptosporidial and microsporidial infections in human immunodeficiency
       virus-infected patients in northeastern Brazil.
 DT    9410
 AU    Wuhib T; Silva TM; Newman RD; Garcia LS; Pereira ML; Chaves CS;
       Wahlquist SP; Bryan RT; Guerrant RL; Sousa A de Q; et al; Division of
       Infectious Diseases, Johns Hopkins University School; of Medicine,
       Baltimore, Maryland 21205-2196.
 SO    J Infect Dis. 1994 Aug;170(2):494-7. Unique Identifier : AIDSLINE
       MED/94308629
 AB    To determine the frequency of the parasitic pathogens in human
       immunodeficiency virus (HIV)-infected patients in a developing world
       setting, 295 stool specimens were examined from 166 HIV-positive
       patients (49% with AIDS) at Sao Jose Hospital, Fortaleza, Brazil, from
       September 1990 to March 1992. Significantly more patients with diarrhea
       (85%) than without (66%) had AIDS or AIDS-related complex (ARC) (P <
       .005). Of the potential parasitic causes of diarrhea, only
       Cryptosporidium parvum and microsporidia were significantly associated
       with diarrheal disease. Infections with C. parvum, but not
       microsporidia, were associated with the rainy season (P < .005). Thus,
       C. parvum and microsporidia are the most common intestinal parasites
       associated with diarrhea in an HIV-infected population in Brazil and are
       associated with advanced HIV disease. The association of C. parvum
       infections with the rainy season suggests that contaminated water may be
       important in its transmission; however, the source of human
       microsporidia requires further investigation.
 DE    Adolescence  Adult  Aged  Animal  AIDS-Related Opportunistic
       Infections/*EPIDEMIOLOGY  Brazil/EPIDEMIOLOGY  Child  Child, Preschool
       Cryptosporidiosis/*EPIDEMIOLOGY  Cryptosporidium parvum/*ISOLATION &
       PURIF  Diarrhea/*EPIDEMIOLOGY  Feces/PARASITOLOGY  Female  Human  Infant
       Male  Microspora/ISOLATION & PURIF  Microspora Infections/*EPIDEMIOLOGY
       Middle Age  Observer Variation  Rain  Retrospective Studies  Risk
       Factors  Seasons  Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).